The Wire
A live feed of biomedical signal — trials, regulatory actions, papers, preprints, and industry moves — harvested automatically by The Vital Record's collectors. Last updated 23 minutes ago.
- business IMU Biosciences nabs $53M funding round to ‘decode’ the immune system
- business As Akeso takes center stage at ASCO, China biotech industry cements its coming of age
- trial Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
- trial Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia
- trial Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma
- trial Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
- trial A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
- trial Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors
- trial Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
- trial Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
- trial A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
- trial BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease
- trial Suzetrigine in Total Hip Arthroplasty
- trial A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
- trial Hydrocortisone Plus Fludrocortisone in High-risk Patients Undergoing for Cardiac Surgery
- trial Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
- trial A Clinical Study to Evaluate the Efficacy and Safety of Bempedoic Acid
- trial A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer
- trial People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
- trial Emetine for Viral Outbreaks (a.k.a. EVOLVE Antiviral Initiative)
- trial A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
- trial A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes
- trial A First in Human Study Investigating the Safety of an Unloaded and Loaded (With a Tetanus-containing Vaccine Booster) Microneedle Patch in Healthy Adults
- trial Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma
- trial A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
- trial Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
- trial A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
- business Ascidian, Lilly ink RNA exon editing pact worth up to $1.9B for genetic kidney diseases
- business Travere scales Everest with $1.1B deal for BTK inhibitor aimed at rare kidney diseases
- business New heights for NewLimit as anti-aging biotech nabs $435M to rejuvenate old cells
- business Fulcrum scraps SCD program, considers options after FDA takes hard line on safety risks
- business Foundation Medicine tallies FDA nod to pair its blood test with Pfizer’s prostate cancer combo
- regulatory FDA Issues Draft Guidance to Help Accelerate Cell and Gene Therapies for Patients
- business Praxis pauses one of its seizure programs after phase 2 fail
- business Abivax stock suffers as cancer cases overshadow stellar efficacy in ulcerative colitis phase 3 trial
- business ASCO: Cardiff posts updated colorectal cancer data ahead of pivotal push
- business MindMaze Therapeutics culls program, ends legacy ops from Relief merger to cut costs
- paper Selinexor Plus Ruxolitinib in JAK Inhibitor-Naïve Myelofibrosis: Phase 3 SENTRY Trial.
- paper NHS consultants are "quiet quitting," senior doctors warn, with industrial ballot under way.
- paper GPs to switch off "nuisance" prescribing software in next phase of collective action.
- paper Knee bracing outcomes for osteoarthritis.
- paper Prostate cancer: The UK National Screening Committee is right to recommend against population screening.
- paper Sexual harassment at medical school: "Shame has to change sides," says student at heart of Manchester University campaign.
- paper Single patient record: A&E impact claims are labelled "drop in the ocean" as Murray refuses to rule out Palantir involvement.
- paper A single, mandatory warning label on unhealthy foods is key to a joined-up approach to obesity.
- paper Racism in healthcare: future doctors are keen to engage with sociology.
- paper Medically tailored meals receipt and healthcare utilization and costs in Massachusetts' Medicaid demonstration.
- paper 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial.
- paper Translating 'food is medicine' from concept to reality.
- paper Author Correction: CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord.
- paper Publisher Correction: White matter micro- and macrostructure brain charts for the human lifespan.
- paper First and last authors more likely to be men in leading science journals.
- paper Chemicals meant to be eco-friendly accumulate aloft.
- business ASCO: Takeda touts ‘tremendous potential’ of Innovent’s PD-1/IL-2 bispecific after seeing survival data
- business ASCO: Celcuity dares to dream of becoming $10B company after breast cancer win over Piqray
- trial A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
- trial A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
- trial AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
- trial Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department
- trial Study of Bitopertin in Participants With EPP or XLP (APOLLO)
- trial Treatment of Active Thyroid Eye Disease With MHB018A in a Randomized, Placebo-Controlled Study
- trial ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
- trial A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
- trial A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
- trial A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
- trial AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
- trial A Study Evaluating 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) In Healthy Infants In China
- trial ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study
- trial Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.
- trial A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
- trial Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
- trial Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
- trial Ensuring Access to Optimal Therapy in CF: The ENACT Study
- trial Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
- trial Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
- trial Famotidine and Antacids for Treatment of Dyspepsia
- trial A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
- trial Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
- trial A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
- trial The Effects of Orexin Antagonism on Fear Extinction in PTSD
- business At ASCO 2026, a ‘paradigm shift’ for a rare gut cancer looms
- business ASCO: Bristol Myers’ $800M bispecific ADC aces China breast cancer study, putting TROP2 drugs on notice
- business ASCO, Ryght AI team up for breast cancer trial site selection
- paper Manageable toxicity is not a label - it is an oxymoron.
- paper Downplaying toxicities in cancer drug trials is not acceptable.
- paper Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial.
- paper Savolitinib in MET-amplified gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial.
- paper Incretin therapies, nutrition and food insecurity in the UK.
- paper SEZ6-targeting antibody-drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial.
- paper Robust projections of risks to the Amazon rainforest.
- paper Science fiction: nine lab-life novels for your holiday reading.
- paper Obesity doesn't equate to ill health: why the 'disease' label doesn't always fit.
- paper Enantioselective hydrogen atom relay via non-covalent catalyst assembly.
- paper Passive heart-rate monitoring during smartphone use in everyday life.
- paper Landmark cancer trial shows success against 'undruggable' cancer - raising hopes for future treatments.
- paper Feynmann's solved 'restaurant dilemma' 50 years ago - now a study confirms his mathematics.
- paper Can Polymarket predict the progress of science, or are subject-experts better?
- paper Smartphone camera takes users' pulse passively during device use.
- paper Poor supervision is pushing young researchers out of academia.
- paper Why it's time to bin recommendation letters in science job applications.
- paper Six ways Gavi will continue to immunise half the world's children amid vaccine backlash and a funding crisis.
- paper Symbiosis of international medical graduates in the NHS.
- paper Galleri cancer test: NHS trial of controversial early detection tool fails to meet main aim, results confirm.
- paper 'Virtual cells' aim to turn raw data into predictive models of biology.
- paper Remembering inventor and activist Hertha Ayrton.
- paper Natural capital accounting needs a way to assess uncertainty.
- paper Is it time to 'cap and trade' credits for research-funding proposals?
- paper Power imbalances in adviser-student relationships need safeguarding.
- paper Global plastics treaty must be built on a foundation of monitoring.
- paper Will AI ruin the social sciences - or revolutionize them?
- paper Better diagnostics could have limited this Ebola outbreak.
- paper The future of science communication is not an article like this.
- paper Daily briefing: What it will take to stop the spiralling Ebola outbreak.
- preprint DKK1 and CKAP4 expression is associated with cervical lymph node metastasis in tongue squamous cell carcinoma
- preprint Cleaner Air for Lower Cardiometabolic Risk: protocol for a double-blind, randomized, sham-controlled trial of HEPA filtration in adults with prediabetes.
- preprint Prevalence and Characteristics of Steatotic Liver Disease in Germany - Magnetic Resonance Imaging in the German National Cohort (NAKO)
- preprint Integrated surveillance resolves Darien paradox of Oropouche virus emergence in Panama migration corridor
- preprint The Sleep-Wake Classification Performance of Pediatric-Trained Machine Learning Algorithms for Raw Accelerometer Data
- preprint Adolescent Weekend Catch-Up Sleep and Sleep Sufficiency: Protective Factors for Depression in Young Adulthood
- preprint Real World Effectiveness of Antipsychotic Treatment on Functional Outcomes Over Ten Years: A National Cohort of Patients in Denmark with Schizophrenia
- preprint HIV-HPV Syndemic and Anal Precancerous Lesions Among MSM and Transgender Women in Pakistan: A Biological Continuum in High-Risk Sexual Networks
- preprint Implementation and impact of a 5-year community-based tuberculosis screening intervention in Cambodia: a mixed-methods pragmatic evaluation using the RE-AIM framework
- preprint Algorithmic Versus Expert Rankings of Large Language Models in Peritoneal Dialysis Prescription Review: A Trap-Embedded Synthetic Benchmark
- preprint Neighborhood Deprivation and Disparities in Blood Pressure Monitoring in Patients with Intracerebral Hemorrhage
- preprint No evidence of cognitive or psychological impact after returning research Alzheimer disease biomarkers: A delayed-start, noninferiority, randomized clinical trial
- preprint The dangers of data double dipping in assessing the classification accuracies of blood biomarkers in Alzheimer's disease and related disorder research
- preprint Plasma biomarker levels and cognitive decline in a heterogenous community-based cohort with multiple comorbidities
- preprint Efficacy of Mobile Application Delivered Lifestyle Interventions in Managing Gestational Weight Gain: A Systematic Review and Meta-Analysis with Meta-Regression
- preprint Sanitation Practices and Child Health Outcomes in Gulu District: The Moderating Effect of Climate, Age, and Water Access.
- preprint Pre-infusion Exhaled breath volatile organic compounds predict severe CRS and ICANS after CAR T-cell therapy
- preprint Survival and neurologic outcomes after re-irradiation in children with diffuse midline glioma and diffuse intrinsic pontine glioma
- business ASCO: Telix tees up pivotal test for Pluvicto challenger while eyeing ‘white space’ on radiopharma canvas
- preprint Automated analysis of feeding dynamics from electromyographic recordings in a blood-sucking insect
- preprint Paraventricular thalamus gates hippocampal coding of salient experiences.
- preprint Developmental genetic response of the zooplanktonic tunicate Oikopleura dioica to marine noise pollution.
- preprint Megaherbivore mortality risk from temperature extremes is buffered by vegetation productivity but amplified by rainfall
- preprint Drought reduces solitary bee reproduction and skews sex ratios
- preprint Using spatial prioritization to navigate current and future tradeoffs when controlling invaders
- preprint Cooperation, privatization and cheating in microbial exoenzyme synthesis: theoretical analysis in view of biotechnological applications
- preprint PFAS exposure is associated with accelerated epigenetic ageing in a wild marine mammal
- preprint Water availability has stronger effects on West Nile virus dynamics in water-limited regions
- preprint Tryptophan became part of the universal genetic code post-LUCA
- preprint GPU accelerated population genetics statistics using pg_gpu
- preprint Functional class 2 CCA-adding enzymes in Asgard archaea and their implications for eukaryogenesis
- preprint Variable jackpot individuals provide most alleles for repeated, rapid adaptation to freshwater by anadromous Threespine Stickleback
- preprint Population genomics reveals divergent lineages in the European peatland plant Drosera rotundifolia
- preprint Modes of natural selection on maternal and zygotic gene expression in Drosophila melanogaster embryos
- preprint Discovery of novel members of the Potyviridae family reveals expanded diversity, a broad host range, and evidence of fungal and oomycete infections
- preprint From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT
- preprint Genomic hallmarks of parasexual reproduction in three hybrid groups of the human pathogen Cryptococcus neoformans
- preprint A functional genomics screen identifies novel drivers of FR900359 resistance in uveal melanoma cells
- preprint Genomic-Adjusted Radiation Dose from Bulk RNA Sequencing for Personalized Radiotherapy
- preprint The genetics of transcriptional responses to stress in yeast
- preprint Environmental heterogeneity facilitates competitive suppression of drug resistance
- preprint Arteriolar GMP signaling revealed by FRET-based real-time measurement in vivo
- preprint Endothelium-Dependent Vasodilation is Impaired in Chronic Spinal Cord Injury and is Associated with Oxidative Stress
- preprint Improving viral protein clustering using both diversified protein profiles and structural information
- preprint Enhanced Irrigation during Extreme Heat Events Preserves Anthocyanins in Cabernet Sauvignon
- preprint Beyond copy number: The regulatory architecture of mitochondrial DNA gene expression
- preprint Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Compared to Macrophage Foam Cells in Human Atherosclerosis